Recombinant Human Betacellulin(Discontinued)
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| Amount : | 20 µg |
| Purification : | Purity: >= 98% by SDS-PAGE gel and HPLC analyses. |
| Content : | This recombinant protein is supplied in lyophilized form. |
| AA sequence : | DGNSTRSPET NGLLCGDPEE NCAATTTQSK RKGHFSRCPK QYKHYCIKGR CRFVVAEQTP SCVCDEGYIG ARCERVDLFY |
| Alternative Name : | BTC |
Source:E.coliBetacellulin is an EGF-related polypeptide growth factor that signals through the EGF receptor. It is produced in several tissues, including the pancreas, small intestine, and in certain tumor cells. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Human betacellulin is initially synthesized as a glycosylated 32.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce the mature sequence. Recombinant Human Betacellulin is a 9.0 kDa monomeric protein, containing 80 amino acid residues, which comprises the mature EGF-homologous portion of the Betacellulin protein.
The ED50 was determined by the dose-dependent stimulation of the proliferation of murine Balb/3T3 cells is <= 0.05 ng/ml, corresponding to a specific activity of >= 2 x 107units/mg.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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