Recombinant Human Beta -NGF(Discontinued)
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| Amount : | 100 µg |
| Purification : | Purity:>= 98% by SDS-PAGE gel and HPLC analyses. |
| Content : | This recombinant protein is supplied in lyophilized form. |
| AA sequence : | SSSHPIFHRG EFSVCDSVSV WVGDKTTATD IKGKEVMVLG EVNINNSVFK QYFFETKCRD PNPVDSGCRG IDSKHWNSYC TTTHTFVKAL TMDGKQAAWR FIRIDTACVC VLSRKAVRRA |
| Alternative Name : | NGF-Beta , beta-Nerve Growth Factor |
Source:E.coliBeta -NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Beta -NGF is a potent neurotrophic factor that signals through its receptor Beta -NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. Beta -NGF also acts as a growth and differentiation factor for B lymphocytes, and enhances B-cell survival. The functional form of Recombinant Human Beta -NGF is a non-covalently-linked homodimer of two 13.5 kDa, polypeptide monomers that each contain 120 amino acids and three disulfide bonds, which are required for biological activity.
Determined by the dose-dependent stimulation of the proliferation of human TF-1 cells. The expected ED50 is <=1.0 ng/ml, corresponding to a specific activity of>= 1 x 106 units/mg.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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