Recombinant Human BD-4(Discontinued)
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Amount : | 20 µg |
Purification : | Purity: >= 98% by SDS-PAGE gel and HPLC analyses. |
AA sequence : | EFELDRICGY GTARCRKKCR SQEYRIGRCP NTYACCLRKW DESLLNRTKP |
Alternative Name : | Beta-Defensin 104, DEFB4 |
Source: E.coli
Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The Alpha-defensins are distinguished from the Beta-defensins by the pairing of their three disulfide bonds. To date, six human Beta-defensins have been identified; BD-1, BD-2, BD-3, BD-4, BD-5 and BD-6. Beta-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they can act as chemoattractants towards immature dendritic cells and memory T cells. The Beta-defensin proteins are expressed as the C-terminal portion of precursors, and are released by proteolytic cleavage of a signal sequence and, in some cases, a propeptide sequence. Beta-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. BD-4 is expressed in the testes, stomach, uterus, neutrophils, thyroid, lungs and kidneys. In addition to its direct antimicrobial activities, BD-4 is chemoattractant towards human blood monocytes. Recombinant Human BD-4 is a 6.0 kDa protein containing 50 amino acid residues.
Determined by its ability to chemoattract human monocytes using a concentration range of 0.1-100.0 ng/ml.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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