Recombinant Human BD-3(Discontinued)
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Amount : | 20 µg |
Purification : | Purity: >= 98% by SDS-PAGE gel and HPLC analyses. |
AA sequence : | GIINTLQKYY CRVRGGRCAV LSCLPKEEQI GKCSTRGRKC CRRKK |
Alternative Name : | Beta-Defensin 3, DEFB3, DEFB103A |
Source: E.coli
Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The Alpha-defensins are distinguished from the Beta-defensins by the pairing of their three disulfide bonds. To date, six human Beta-defensins have been identified; BD-1, BD-2, BD-3, BD-4, BD-5 and BD-6. Beta-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they can act as chemoattractants towards immature dendritic cells and memory T cells. The Beta-defensin proteins are expressed as the C-terminal portion of precursors, and are released by proteolytic cleavage of a signal sequence and, in some cases, a propeptide sequence. Beta-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. Recombinant Human BD-3 is a 5.1 kDa protein containing 45 amino acid residues.
Exhibits antimicrobial activity against gram-positive bacteria S. aureus and gram-negative P. aeruginosa and E.coli.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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