Recombinant Human BAFF protein with N-terminal human Fc
Figure 1. Human BAFF Protein, hFc Tag on SDS-PAGE under reducing condition.
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| Amount : | 50 µg |
| Purification : | The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| Content : | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization. |
| Storage condition : | Store at -80°C for 12 months (Avoid repeated freezing and thawing) |
| AA sequence : | hFc(Glu99-Ala330) BAFF(Ala134-Leu285) |
| Uniprot ID : | Q9Y275 |
| Alternative Name : | TNFSF13B,BAFF,BLYS,CD257,DTL,TALL1,THANK,TNFSF20,ZTNF4,TALL-1 |
Expression Host : HEK293
The protein has a predicted molecular mass of 43.2 kDa after removal of the signal peptide.The apparent molecular mass of BAFF-hFc is approximately 50-55 kDa due to glycosylation.
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
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