Recombinant Human Amphiregulin(Discontinued)
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| Amount : | 50 µg |
| Purification : | Purity: >= 95% by SDS-PAGE gel and HPLC analyses. |
| AA sequence : | SVRVEQVVKP PQNKTESENT SDKPKRKKKG GKNGKNRRNR KKKNPCNAEF QNFCIHGECK YIEHLEAVTC KCQQEYFGER CGEKSMKTHS MIDSSLSK |
| Alternative Name : | AR, AREG, Colorectum cell-derived growth factor (CRDGF) |
Source: E.coli
Amphiregulin is an EGF related growth factor that signals through the EGF/TGF-Alpha receptor, and stimulates growth of keratinocytes, epithelial cells and some fibroblasts. Amphiregulin also inhibits the growth of certain carcinoma cell lines. Synthesized as a transmembrane protein, AmphiregulinÂ’s extracellular domain is proteolytically processed to release the mature protein. There are 6 conserved cysteine residues, which form 3 intramolecular disulfide bonds essential for biological activity. Recombinant Human Amphiregulin is an 11.3 kDa glycoprotein consisting of 98 amino acid residues.
Determined by its ability to stimulate the proliferation of mouse Balb/c 3T3 cells. The expected ED50 for this effect is 5-10 ng/ml.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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