Recombinant Human Activin Receptor 2B/Activin RIIB/ACVR2B (C-Fc-6His)

Product code: 32-9704

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  •   500 µg

  •  50 µg

  • $1,304.00 

  • $413.00 

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Amount : 50 µg
Content : Lyophilized from a 0.2 µm filtered solution of 20mM PB,150mM NaCl,pH7.4.
AA sequence : Recombinant Human Activin Receptor IIB is produced by our Mammalian expression system and the target gene encoding Ser19-Thr134 is expressed with a Fc, 6His tag at the C-terminus.
Alternative Name : Activin Receptor Type-2B, Activin Receptor Type IIB, ACTR-IIB, ACVR2B
Source : Human Cells;
Activin proteins that belong to the transforming growth factor-beta (TGF-Beta) superfamily, exert their biological actions by binding to heteromeric receptor complexes of type I and type II serine/threonine kinase receptors. On ligand binding, type I and II receptors form a stable complex, resulting in phosphorylation of type I receptors by type II receptors with constitutive kinase activity, and subsequently initiates the activation of downstream molecules including the endogenous Smads. ActRIIB, also known as ActRIIB, is a type II receptor containing an extracellular domain (ECD), a transmembrane segment, and a cytoplasmic region that includes the kinase domain. ActRIIB is a receptor for activin A, activin B and inhibin A. Multiple ActRIIB isoforms can also be generated, which bind activin isoforms with different affinities.
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