Recombinant Human Activin B(Discontinued)
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| Amount : | 5 µg |
| Purification : | Purity:>= 95% by SDS-PAGE gel and HPLC analyses. |
| Content : | This recombinant protein is supplied in lyophilized form. |
| AA sequence : | GLECDGRTNL CCRQQFFIDF RLIGWNDWII APTGYYGNYC EGSCPAYLAG VPGSASSFHT AVVNQYRMRG LNPGTVNSCC IPTKLSTMSM LYFDDEYNIV KRDVPNMIVE ECGCA |
| Alternative Name : | Activin beta-B, Inhibin beta-2 |
Source:Â Hi-5 Insect cells
Activin B is a TGF-Beta family member that exhibits a wide range of biological activities, including regulation of embryogenesis, osteogenesis, hematopoiesis, reproductive physiology and hormone secretion from the hypothalamic, pituitary and gonadal glands. Â Activin B, like certain other members of the TGF-Beta family, signals through the ActRII receptor (Activin Receptor type II). Â Activins are homodimers or heterodimers of different Beta subunits. Â They are produced as precursor proteins with an amino terminal propeptide that is cleaved to release the C-terminal bioactive ligand. Â Human Activin B is a 25.6 kDa disulfide-linked homodimer consisting of two Beta B chains, each containing 115 amino acid residues.
Activin B is a TGF-Beta family member that exhibits a wide range of biological activities, including regulation of embryogenesis, osteogenesis, hematopoiesis, reproductive physiology and hormone secretion from the hypothalamic, pituitary and gonadal glands. Â Activin B, like certain other members of the TGF-Beta family, signals through the ActRII receptor (Activin Receptor type II). Â Activins are homodimers or heterodimers of different Beta subunits. Â They are produced as precursor proteins with an amino terminal propeptide that is cleaved to release the C-terminal bioactive ligand. Â Human Activin B is a 25.6 kDa disulfide-linked homodimer consisting of two Beta B chains, each containing 115 amino acid residues.
The ED50 as determined by its ability to inhibit the proliferation of murine MPC-11 cells is <=2.0 ng/ml, corresponding to a specific activity of>= 5 x 105 units/mg.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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