Recombinant Hirudo medicinalis Hirudin-1/Lepirudin (C-His)
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| Amount : | 50 µg |
| Content : | Supplied as a 0.2 um filtered solution of PBS pH7.4 |
| AA sequence : | Recombinant Hirudo medicinalis Hirudin-1 is produced by Pichia pastoris. The target gene encoding Y3-Q65 is expressed with a 6His tag at the C-terminus. |
| Alternative Name : | Hirudin-1; Lepirudin; Hirudin variant-1 |
Source : Pichia pastoris;
Hirudin is a secreted protein that belongs to the protease inhibitor I14 (hirudin) family. Hirudin is a potent thrombin-specific protease inhibitor. It forms a stable non-covalent complex with alpha-thrombin, thereby abolishing its ability to cleave fibrinogen. In nature, Hirudin is found in the salivary glands of Hirudo medicinalis that has a blood anticoagulant property. Hirudin can be used to treat heparin-induced thrombocytopenia.
Hirudin is a secreted protein that belongs to the protease inhibitor I14 (hirudin) family. Hirudin is a potent thrombin-specific protease inhibitor. It forms a stable non-covalent complex with alpha-thrombin, thereby abolishing its ability to cleave fibrinogen. In nature, Hirudin is found in the salivary glands of Hirudo medicinalis that has a blood anticoagulant property. Hirudin can be used to treat heparin-induced thrombocytopenia.
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