Recombinant E.coli RNA-splicing ligase RtcB
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| Amount : | 50 µg |
| Content : | Supplied as a 0.2 um filtered solution of 2umM HEPES, 30umM NaCl,10%glycerol, umM DTT,0.umM EDTA,pH7.5. |
| AA sequence : | Recombinant E.coli RNA-splicing ligase RtcB is produced by E.coli. The target gene encoding M1-G408 is expressed. |
| Alternative Name : | 3'-phosphate/5'-hydroxy nucleic acid ligase; rtcB; yhgL |
Source : E. coli;
RNA-splicing ligase RtcB is a member of RtcB family. It is a GTP-dependent RNA ligase that is involved in tRNA splicing and RNA repair. RtcB rejoins broken stem-loops of tRNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends. RtcB can also act as a DNA ligase in case of DNA damage by splicing 'dirty' DNA breaks, characterized by 3'-phosphate (or cyclic-phosphate) and 5'-hydroxy ends that cannot be sealed by classical DNA ligases.
RNA-splicing ligase RtcB is a member of RtcB family. It is a GTP-dependent RNA ligase that is involved in tRNA splicing and RNA repair. RtcB rejoins broken stem-loops of tRNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends. RtcB can also act as a DNA ligase in case of DNA damage by splicing 'dirty' DNA breaks, characterized by 3'-phosphate (or cyclic-phosphate) and 5'-hydroxy ends that cannot be sealed by classical DNA ligases.
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