Recombinant Cynomolgus CD163 (C-His)
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| Amount : | 50 µg |
| Content : | Lyophilized from a 0.2 um filtered solution of PBS, pH7.4 |
| AA sequence : | Recombinant Cynomolgus CD163 is produced by Human 293 Cells. The target gene encoding M1-S1050 is expressed with a 10His tag at the C-terminus. |
| Alternative Name : | CD163 antigenscavenger receptor cysteine-rich type 1 protein M130; CD163 molecule; CD163; GHI/61; HbSR; Hemoglobin scavenger receptor; M130; M130macrophage-associated antigen; MM130; RM3/1 |
Source : Human 293 Cells;
CD163 is a type I transmembrane glycoprotein that belongs to group B of the cysteine-rich scavenger receptor family. The expression of CD163 is essential and is induced by glucocorticoids, IL-10, IL-6, or endotoxin on circulating monocytes, tissue macrophages. CD163 plays an important role in the clearance of hemoglobin-haptoglobin (Hb-Hp) complexes in the liver, spleen and circulation. A soluble form of CD163 exists in plasma, commonly known as sCD163. sCD163 is generated by ectodomain shedding of the membrane-bound receptor. sCD163 is upregulated in a wide range of inflammatory diseases including liver cirrhosis, type 2 diabetes, macrophage activation syndrome, Gaucher's disease, sepsis, HIV infection, rheumatoid arthritis and Hodgkin Lymphoma.
CD163 is a type I transmembrane glycoprotein that belongs to group B of the cysteine-rich scavenger receptor family. The expression of CD163 is essential and is induced by glucocorticoids, IL-10, IL-6, or endotoxin on circulating monocytes, tissue macrophages. CD163 plays an important role in the clearance of hemoglobin-haptoglobin (Hb-Hp) complexes in the liver, spleen and circulation. A soluble form of CD163 exists in plasma, commonly known as sCD163. sCD163 is generated by ectodomain shedding of the membrane-bound receptor. sCD163 is upregulated in a wide range of inflammatory diseases including liver cirrhosis, type 2 diabetes, macrophage activation syndrome, Gaucher's disease, sepsis, HIV infection, rheumatoid arthritis and Hodgkin Lymphoma.
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