Recombinant 2019-nCoV S1 Protein (Active)
Structural diagrams of spike glycoproteins of SARS-CoV, MERS-CoV, and SARS-CoV-2. All spike proteins of coronaviruses contain S1 subunit and S2 subunit, which were divided by the S cleavage sites. FP, fusion peptide; HR, heptad repeat 1 and heptad repeat 2; RBD, receptor-binding domain, contains core binding motif in the external subdomain; SP, signal peptide. Adapted from Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARS-CoV-2. Liu Z, et al. J Med Virol. 2020 Feb 26. doi: 10.1002/jmv.25726.
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| Amount : | 500 µg |
| Purification : | Greater than 85% as determined by reducing SDS-PAGE. |
| Content : | Supplied as a 0.2 µM filtered solution of PBS, pH 7.4 |
| Storage condition : | Reconstituted protein solution should be stored at <-20°C. |
| AA sequence : | Expression Region: Recombinant 2019-nCoV S1 Protein is produced by our Mammalian expression system and the target gene encoding Gln14-Arg685 is expressed. |
| Alternative Name : | S1 protein; 2019-nCoV S1 protein; coronavirus S1 Protein; cov S1 Protein |
Source : Mammalian Expression ; Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biological processes that include coagulation, apoptosis, cancer development and progression, and the innate immune response. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, CEACAM etc.. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells throµgh interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
Calculated MW78.3kDa
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
Sałkowska, A., Karwaciak, I., Karaś, K., Dastych, J. and Ratajewski, M.
SARS-CoV-2 Proteins Induce IFNG in Th1 Lymphocytes Generated from CD4+ Cells from Healthy, Unexposed Polish Donors.
Vaccines 2020, 8(4), 673;https://doi.org/10.3390/vaccines8040673
Paidi, R.K., Jana, M., Mishra, R.K., Dutta, D., Raha, S. & Pahan , K.
ACE-2-interacting Domain of SARS-CoV-2 (AIDS) Peptide Suppresses Inflammation to Reduce Fever and Protect Lungs and Heart in Mice: Implications for COVID-19 Therapy.
Journal of Neuroimmune Pharmacology (2021). https://doi.org/10.1007/s11481-020-09979-8
Karwaciak, I.; Sałkowska, A.; Karaś, K.; Dastych, J.; Ratajewski, M.
Nucleocapsid and Spike Proteins of the Coronavirus SARS-CoV-2 Induce IL6 in Monocytes and Macrophages—Potential Implications for Cytokine Storm Syndrome.
Vaccines 2021, 9, 54. https://doi.org/10.3390/vaccines9010054.
Jugler C, Sun H, Chen Q.
SARS-CoV-2 Spike Protein-Induced Interleukin 6 Signaling Is Blocked by a Plant-Produced Anti-Interleukin 6 Receptor Monoclonal Antibody.
Vaccines. 2021; 9(11):1365. https://doi.org/10.3390/vaccines9111365
Wei C, Datta PK, Siegerist F, Li J, Yashwanth S, Koh KH, Kriho NW, Ismail A, Luo S, Fischer T, Amber KT, Cimbaluk D, Landay A, Endlich N, Rappaport J; Michigan Medicine COVID−19 Investigators; Hayek SS, Reiser J.
SuPAR mediates viral response proteinuria by rapidly changing podocyte function.
Nat Commun. 2023 Jul 21;14(1):4414. doi: 10.1038/s41467-023-40165-5. PMID: 37479685; PMCID: PMC10362037.
Ciszewski WM, Wozniak LA, Sobierajska K.
SARS-CoV-2 S and N protein peptides drive invasion abilities of colon cancer cells through TGF-β1 regulation.
Biochim Biophys Acta Mol Cell Res. 2023 Oct;1870(7):119541. doi: 10.1016/j.bbamcr.2023.119541. Epub 2023 Jul 17.
PMID: 37468071.
Jugler C, Sun H, Chen Q.
SARS-CoV-2 Spike Protein-Induced Interleukin 6 Signaling Is Blocked by a Plant-Produced Anti-Interleukin 6 Receptor Monoclonal Antibody.
Vaccines (Basel). 2021 Nov 20;9(11):1365. doi: 10.3390/vaccines9111365.
PMID: 34835296; PMCID: PMC8623585.
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