Rat Interleukin-17AF Heterodimer
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| Amount : | 100 µg |
| Purification : | Reducing and Non-Reducing SDS PAGE at >= 95% |
| Content : | Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA) Sterile water at 0.1 mg/mL |
| Storage condition : | Store at -20°C |
| AA sequence : | IL-17A: MAVLIPQSSV CPNAEANNFL QNVKVNLKVL NSLSSKASSR RPSDYLNRST SPWTLSRNED PDRYPSVIWE AQCRHQRCVN AEGKLDHHMN SVLIQQEILV LKREPEKCPF TFRVEKMLVG VGCTCVSSIV RHAS IL-17F:MARRNPKVGL SALQKAGNCP PLEDNSVRVD IRIFNQNQGI SVPRDFQNRS SSPWD YNITR DPDRFPSEIA EAQCRHSGCI NAQGQEDGSM NSVPIQQEIL VLRREPQGCS NSFRLEKMLI KVGCTCVTPI VHHAA |
| Gene : | Il17a |
| Uniprot ID : | Q61453/Q5BJ95 |
| Alternative Name : | Ctla8, Il17, Cytotoxic T-lymphocyte-associated antigen 8 |
Source: Genetically modified E.coli.
Predicted MW:Â Dimer, 30.2 kDa ((IL-17A=134; IL-17F=135; Total=269 amino acids) aa)
 Interleukin 17AF (IL-17AF) is a heterodimer that is composed of the interleukin 17A (IL-17A) and interleukin 17F (IL-17F) members of the IL-17 family of cytokines.  IL-17AF is produced by T helper 17 cells (Th17) following interleukin 23 (IL-23) stimulation.  IL-17AF signals through the IL-17RA/IL-17RC receptor complex and functions to regulate inflammatory responses.  IL-17AF induces chemokine and airway neutrophilia production, similar in function to IL-17A and IL-17F homodimers.  In regard to these functions, IL-17AF is less active than the IL-17A homodimer and shows greater activity than the IL-17F homodimer.  Human and rat IL-17AF are active on mouse cells.Â
Predicted MW:Â Dimer, 30.2 kDa ((IL-17A=134; IL-17F=135; Total=269 amino acids) aa)
 Interleukin 17AF (IL-17AF) is a heterodimer that is composed of the interleukin 17A (IL-17A) and interleukin 17F (IL-17F) members of the IL-17 family of cytokines.  IL-17AF is produced by T helper 17 cells (Th17) following interleukin 23 (IL-23) stimulation.  IL-17AF signals through the IL-17RA/IL-17RC receptor complex and functions to regulate inflammatory responses.  IL-17AF induces chemokine and airway neutrophilia production, similar in function to IL-17A and IL-17F homodimers.  In regard to these functions, IL-17AF is less active than the IL-17A homodimer and shows greater activity than the IL-17F homodimer.  Human and rat IL-17AF are active on mouse cells.Â
Endotoxin: Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
Centrifuge vial before opening, Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws. Upon reconstitution, a small amount of visible precipitate can be expected. A 10% overfill has been added to the total material vialed to compensate for this loss.  Â
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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