Rat Anti-Mouse Ly-6A/E-LENA™ (Low Endotoxin No Azide) Clone: D7
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| Amount : | 0.5 mg |
| Isotype : | Rat IgG2a, kappa |
| Content : | 0.5 mg/ml, 1.0 ml, Supplied in PBS |
| Storage condition : | Store at -20°C |
Ly-6A/E, also known as Sca-1, is a member of the Ly-6 multigene family of type V glycophosphatidylinositol-anchored cell surface proteins. It is expressed on multipotent hematopoietic stem cells in bone marrow of mice with both the Ly-6.1 and Ly-6.2 allotypes. In the periphery, Ly-6A/E exhibits a pattern of expression which is based on differences between the two allotypes. Ly-6.1 strains (e.g., A, BALB/c, CBA, C3H/He, DBA/1, NZB) have few Ly-6A/E+ resting peripheral lymphocytes whereas Ly-6.2 strains (e.g., AKR, C57BL, C57BR, C57L, DBA/2, PL, SJL, SWR, 129) have relatively high numbers of Ly-6A/E+ lymphocytes. The expression of Ly-6A/E is dramatically upregulated in all strains upon cellular activation. Studies with the monoclonal antibody D7 suggest that Ly-6A/E may be involved in B and T lymphocyte responses and it appears that the antigen may be required for T-cell receptor-mediated T-cell activation.
1: Hordeaux J, Yuan Y, Clark PM, Wang Q, Martino RA, Sims JJ, Bell P, Raymond A, Stanford WL, Wilson JM. The GPI-Linked Protein LY6A Drives AAV-PHP.B Transport across the Blood-Brain Barrier. Mol Ther. 2019 Feb 20. pii: S1525-0016(19)30054-1. doi: 10.1016/j.ymthe.2019.02.013. [Epub ahead of print] PubMed PMID: 30819613.
| Subcellular location: | Cell membrane |
| Post transnational modification: | Not phosphorylated. |
| Tissue Specificity: | Widely expressed. |
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