Rat Anti-Mouse CD117

Product code: 31-2169

Clone name : 2B8
Clonality : Monoclonal
Application : IHC, IP, FACS, IHC-Fr
Conjugate : Unconjugated

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0.5 mg
$476.00 

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Amount : 0.5 mg
Isotype : Rat IgG2b, kappa
Content : 0.5 mg/ml, 1.0 ml, Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Storage condition : Store at 2-8°C
Gene : Kit
Gene ID : 16590
Uniprot ID : P05532
Alternative Name : Kit, Sl
Subcellular location: Cytoplasm
Post transnational modification: Autophosphorylated on tyrosine residues. KITLG/SCF binding promotes autophosphorylation of isoform 1 and isoform 2. Isoform 1 shows low levels of tyrosine phosphorylation in the absence of added KITLG/SCF, while isoform 2 requires stimulation by KITLG/SCF for phosphorylation (in vitro). Phosphorylation of Tyr-573 is required for interaction with PTPN6/SHP-1. Phosphorylation of Tyr-571 is required for interaction with PTPN11/SHP-2. Phosphorylated tyrosine residues are important for interaction with specific binding partners.
Tissue Specificity: Isoform 1 and isoform 2 are detected in bone marrow cells, spermatogonia and spermatocytes, but not in round spermatids, elongating spermatids and spermatozoa. Isoform 3 is detected in round spermatids, elongating spermatids and spermatozoa, but not in spermatogonia and spermatocytes (at protein level). Isoform 1 is widely expressed and detected in fetal liver and bone marrow. Isoform 3 is detected in bone marrow cells enriched in hematopoietic stem cells.
BioGrid: 200957. 18 interactions.
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