Rabbit Polyclonal Antibody to ERK2(Discontinued)
Figure-1 : Western blot analysis of ERK2 Antibody at 1 µg/ml on HeLa, NIH/3T3 cell lysate & Rat brain tissue. IRDye 800 Conjugated Goat Anti-Rabbit IgG was used as secondary antibody.
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| Format : | Purified |
| Amount : | 40 µg |
| Isotype : | Rabbit IgG |
| Purification : | Immunoaffinity chromatography |
| Content : | 0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide |
| Storage condition : | The antibody is stable in lyophilized form if stored at -20°C or below. The reconstituted antibody can be stored for 2-3 weeks at 2-8°C. For long term storage, aliquot and store at -20°C or below. Avoid repeated freezing and thawing cycles. |
| Gene : | MAPK1 |
| Gene ID : | 5594 |
| Uniprot ID : | P28482 |
| Alternative Name : | ERK2 pAb, ERT1, Extracellular signal-regulated kinase 2, MAP kinase isoform p42, Mitogen-activated protein kinase 2, ERK2, PRKM1, PRKM2 |
| Immunogen Information : | KLH-coupled synthetic peptide corresponding to 300-322 residues of human ERK2 . |
ERK (extracellular signal regulated kinase), also known as MAPK (mitogen activated protein kinase) includes two closely related isoforms ERK1 and ERK2 (p44 and p42 MAP Kinase). ERK1/2 signaling pathway can be activated in response to a diverse range of extracellular stimuli including mitogens, growth factors, and cytokines. The downstream effects of ERK1/2 signaling pathway are linked to the regulation of cell growth and differentiation as well as the cytoskeleton. Downstream targets of ERK1/2 contain p90RSK and the transcription factor Elk-1. ERK1 and ERK2 are phosphorylated within the activation loop on both a threonine and a tyrosine residue (within a Thr-Glu-Tyr motif) by MEKs (MAPK/ERK kinases), thereby greatly elevating the activity of ERK1/2. ERK1/2 are negatively regulated by a family of dual-specificity (Thr/Tyr) MAPK phosphatases. Rabbit Anti-ERK2 Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide (KRIEVEQALAHPYLEQYYDPSDE) corresponding to 300-322 residues of human ERK2 (Swiss Prot: P28482).
ELISA: 0.05-0.2 µg/ml
Western blot: 1-2 µg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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