Polyclonal Antibody to VEGFR2 (Phospho-Tyr1214)

Product code: 35-1083

Clonality : Polyclonal
Application : WB, IHC, IF
Reactivity : Human, Mouse, Rat

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Available Pack Size(s)

  •   50 µl

  •  100 µl

  • $374.00 

  • $437.00 

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Format : Purified
Amount : 100 µl
Isotype : Rabbit IgG
Content : Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : KDR
Gene ID : 3791
Uniprot ID : P35968
Alternative Name : FLK1, KDR, VGFR2, VGR2, kinase insert domain receptor
Immunogen Information : Peptide sequence around phosphorylation site of tyrosine 1214 (F-H-Y(p)-D-N) derived from Human VEGFR2.
Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions Lamalice L, et al. (2004). Oncogene.23(2): 434-445. Takahashi T, et al. (2001). EMBO J .20(11): 2768-2778.

Predicted MW: 230kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Secreted
Post transnational modification: The inhibitory disulfide bond between Cys-1024 and Cys-1045 may serve as a specific molecular switch for H(2)S-induced modification that regulates VEGFR2 function.
Tissue Specificity: Detected in cornea (at protein level). Widely expressed.
BioGrid: 109992. 60 interactions.
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