Polyclonal Antibody to USP7
Fig-1: Western blot analysis of USP7. Anti-USP7 antibody (11-3009) was used at 4 µg/ml on A431 lysate.
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| Format : | Purified |
| Amount : | 100 µg |
| Isotype : | Rabbit IgG |
| Purification : | Protein A Chromatography |
| Content : | 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
USP7 (ubiquitin specific peptidase 7) is a deubiquitinating enzyme that prevents protein degradation by removing poly-ubiquitin chains from its substrates. It regulates stability of a number of human transcription factors and tumor suppressors and plays a critical role in the development of several types of cancer, including prostate and small cell lung cancer.USP7 regulates Pol-eta (DNA polymerase eta) stability through both indirect and direct mechanisms. It regulates the stability of the DNA maintenance methyltransferase. Diseases associated with USP7 include UV-sensitive syndrome.
Western blot analysis: 2-4 µg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Nucleus, Cytoplasm, Nucleus, Chromosome |
| Post transnational modification: | Isoform 1 and isoform 2: Polyubiquitinated by herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110; leading to its subsequent proteasomal degradation. Isoform 1: Ubiquitinated at Lys-869. |
| Tissue Specificity: | Widely expressed. Overexpressed in prostate cancer. |
| BioGrid: | 113622. 341 interactions. |
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