Polyclonal Antibody to TrkA (Ab-791)
Figure 1: Immunofluorescence staining of methanol-fixed Hela cells using TrkA(Ab-791) Antibody 35-1647 .
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Shipping Info:
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| Format : | Purified |
| Amount : | 100 µl |
| Isotype : | Rabbit IgG |
| Content : | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
| Gene : | NTRK1 |
| Gene ID : | 4914 |
| Uniprot ID : | P04629 |
| Alternative Name : | High affinity nerve growth factor receptor precursor, NTRK1, Slow nerve growth factor receptor, TRK, TRK1 transforming tyrosine kinase protein |
| Immunogen Information : | Peptide sequence around aa.789~793 (P-V-Y-L-D) derived from Human TrkA. |
Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.
Predicted MW: 140kd, Immunofluorescence: 1:100~1:200
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cell membrane, Early endosome membrane, Late endosome membrane, Recycling endosome membrane |
| Post transnational modification: | Ubiquitinated (PubMed:27445338). Undergoes polyubiquitination upon activation; regulated by NGFR (PubMed:27445338). Ubiquitination by NEDD4L leads to degradation (PubMed:27445338). Ubiquitination regulates the internalization of the receptor (By similarity). |
| Tissue Specificity: | Isoform TrkA-I is found in most non-neuronal tissues. Isoform TrkA-II is primarily expressed in neuronal cells. TrkA-III is specifically expressed by pluripotent neural stem and neural crest progenitors. |
| BioGrid: | 110969. 1947 interactions. |
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