Polyclonal antibody to TRAF-3
Fig:1 Western blot analysis of TRAF3 in various tumor cell lines using 20-1099 at 1:2000. TRAF3 is observed at ~67 kDa.
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| Format : | Sera |
| Amount : | 50 µl |
| Isotype : | Rabbit IgG |
| Content : | 50 µl sera |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
This antibody recognizes TRAF3. Human TRAF3 is a member of the, TRAF (TNF Receptor Associated Factor) protein family, having an approximate molecular weight of 568 amino acid.TRAF3 is a CD40 binding protein that contains a RING finger DNA binding motif and Cys/His rich region and coiled COIL domain. Like TRAF1 (TNF Receptor Associated Factor-1) and TRAF2 (TNF Receptor Associated Factor-2), it contains a C-terminal TRAF domain and has an apparent molecular mass of 64 kDa.TRAF3 is involved in mediating the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the, LtBetaR (Lymphotoxin-Beta Receptor) signaling complex, which induces NF-KappaB activation and cell death initiated by LT-Beta (Lymphotoxin-Beta) ligation.
WB: 1:1000-1:2000, IHC (paraffin): 1:1000-1:5000, IHC (frozen): Users should optimize, IP: 1:50-1:200
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cytoplasm, Endosome, Mitochondrion |
| BioGrid: | 113039. 112 interactions. |
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