Polyclonal antibody to TRAF-2
Fig:1 Immunhistochemical analysis of TRAF2 in formalin-fixed, paraffin-embedded normal human thymus sections using 20-1095 at 1:2000. A-C, successively higher magnifications. Hematoxylin-eosin counterstain.
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| Format : | Sera |
| Amount : | 50 µl |
| Isotype : | Rabbit IgG |
| Content : | 50 µl sera |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
This antibody recognizes TRAF2, which is a member of TRAF (TNF receptor-associated factor) adapter proteins composed 501 amino acids. It Links TNFRs (TNF Receptors) to the SAPKs (Stress-Activated Protein Kinases) and p38s. TRAF2 can activate ASK1 (Apoptosis Signal-Regulating Kinase-1) in vivo and can interact in vivo with the amino- and carboxyl-terminal noncatalytic domains of the ASK1 polypeptide. Expression of the amino-terminal noncatalytic domain of ASK1 can inhibit TNF and TRAF2 activation of SAPK. TRAF2 is a potential mediator of CD40 signaling. In vitro, TRAF2 and TRAF3 bind to the CD40 Cytoplasmic Tail (CD40CT) with much higher affinity than TRAF5 and TRAF6 (TNF Receptor Associated Factor-6) and that TRAF2 and TRAF3 bind to different residues of the CD40CT. The TRAF2-binding site of the CD40CT is critical for NF-KappaB and SAPK activation, as well as the UP-regulation of the ICAM1 (Intercellular Adhesion Molecule-1).
WB: 1:1000-1:2000, IHC (paraffin): 1:1000-1:5000, IHC (frozen): Users should optimize, IP: 1:50-1:200
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cytoplasm |
| BioGrid: | 113038. 355 interactions. |
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