Polyclonal antibody to TRAF-1
Fig:1 Western blot analysis of TRAF1 in normal human tissues using 20-1093 at 1:2000. TRAF1 is observed at 50 kDa. Additional bands of lower molecular weight were seen in some cases, and may represent TRAF1 degradation fragments.
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| Format : | Sera |
| Amount : | 50 µl |
| Isotype : | Rabbit IgG |
| Content : | 50 µl sera |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
This antibody recognizes TRAF1. TRAF1 is a member of TRAF (TNF receptor-associated factor) adapter proteins composed 416 amino acids. The members of this family link a wide variety of cell surface receptors to diverse signaling cascades leading to the activation of NF-kB and mitogen-activated protein kinases. TRAFs are major signal transducers for both the TNF and IL- 1/TLR receptor superfamilies and collectively play important functions in both adaptive and innate immunity. TRAFs also interact with a variety of proteins that regulate receptor-induced cell death or survival, and TRAF-mediated signaling can promote cell survival or interfere with death receptor-induced apoptosis.
WB: 1:1000-1:2000, IHC (paraffin): 1:1000-1:5000, IHC (frozen): Users should optimize, IP: 1:50-1:200
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Post transnational modification: | Polyubiquitinated by BIRC2 and/or BIRC3, leading to its subsequent proteasomal degradation. |
| BioGrid: | 113037. 219 interactions. |
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