Polyclonal Antibody to TIP60
Figure-1: Western blot analysis of TIP60. Anti-TIP60 antibody (11-8062) was used at 2 µg/ml on (1) h Kidney, (2) MCF-7 and (3) Hela lysates.
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| Format : | Purified |
| Amount : | 100 µg |
| Isotype : | Rabbit IgG |
| Purification : | Protein A Chromatography |
| Content : | 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
TIP60 (60 kDa Tat-interactive protein) alternatively called as Lysine acetyltransferase 5 (KAT5) or Histone acetyltransferase KAT5 is a member of MYST protein family with four isoforms (58, 53, 61 and 56 kDa). TIP60 plays important roles in regulating chromatin remodeling, transcription, DNA repair and apoptosis. TIP60 causes transcription activation by acetylating nucleosomal histones H4 and H2A. Mutations at gene level are associated with diseases like HIV-1, and Kaposis sarcoma. TIP60 is mainly expressed in brain tissue.
Western blot analysis: 2-4 µg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Nucleus, Nucleus, Cytoplasm |
| Post transnational modification: | Autoacetylation at Lys-327 is required for proper function. |
| BioGrid: | 115779. 228 interactions. |
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