Polyclonal Antibody to TAB3
Fig-1: Western blot analysis of TAB3. Anti-TAB3 antibody (11-6001) was used at 4 µg/ml on HepG2 lysate.
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| Format : | Purified |
| Amount : | 100 µg |
| Isotype : | Rabbit IgG |
| Purification : | Protein A Chromatography |
| Content : | 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
TAB3 (TGF-beta activated kinase 1/MAP3K7 binding protein 3) has CUE domain and RanBP2-type zinc finger (NZF) domains mediates binding to two consecutive 'Lys-63'-linked ubiquitins. It contains 712 amino acids. TAB3 is a mediator of MAP3K7 activation and it forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation of TNF or IL-1. This successive MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor and AP1 transcription factor. This protein shows interaction with TAB1, TAB2, MAP3K7, TRAF2 and TRAF6. It has 2 isoforms produced by alternative splicing. Isoform 2 may be an oncogenic factor. TAB3 involved in necrosis and tumors like disease.
Western blot analysis: 4-6 µg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Post transnational modification: | Phosphorylated at Ser-506 by MAPKAPK2 and MAPKAPK3 following IL1 treatment. |
| Tissue Specificity: | Widely expressed. Constitutively overexpressed in certain tumor tissues. Isoform 1 is a major transcript while isoform 2 is a minor transcript. |
| BioGrid: | 129216. 28 interactions. |
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