Polyclonal Antibody to ST2
Fig-1: Western blot analysis of ST2V or ST2. Anti- ST2V or ST2 antibody (11-3002) was used at 2 µg/ml on Brain lysate.
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| Format : | Purified |
| Amount : | 100 µg |
| Isotype : | Rabbit IgG |
| Purification : | Protein A Chromatography |
| Content : | 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
ST2V or ST2 is a member of the interleukin 1 receptor family. It acts as receptor for interleukin-33 (IL33) and its stimulation recruits MYD88, IRAK1, IRAK4 and TRAF6, followed by phosphorylation of MAPK3/ERK1. Diseases associated with ST2V are yellow fever and allergic conjunctivitis. It is highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine and has four isoforms produced by alternate splicing.
Western blot analysis: 2-4 µg/ml
This antibody detects ~34 kDa band. The size corresponds to Isoform 2 (Uniprot ID-Q01638-2) of ST2, the right size is ~63 kDa.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cell membrane |
| Tissue Specificity: | Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle. Expressed on T-cells in fibrotic liver; at protein level. Overexpressed in fibrotic and cirrhotic liver. |
| BioGrid: | 114613. 8 interactions. |
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