Polyclonal Antibody to SPARC/Osteonectin
Fig-1: Expression analysis SPARC. Anti-SPARC antibody (11-7512) was used at 2 µg/ml on U87 lysate.
Roll over image to zoom in
Shipping Info:
Order now and get it on Tuesday November 26, 2024
Same day delivery FREE on San Diego area orders placed by 1.00 PM
| Format : | Purified |
| Amount : | 100 µg |
| Isotype : | Rabbit IgG |
| Purification : | Protein A Chromatography |
| Content : | 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| Storage condition : | Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles. |
SPARC (Secreted protein, acidic, cysteine-rich) is a glycoprotein that binds to collagen type I and other proteins in the extracellular matrix. It is involved in normal tissue remodeling as it regulates the deposition of extracellular matrix, and also plays a role in neoplastic transformation. It modulates interactions between tumoral cells and the peri-tumoral stroma. Homozygous mutations in SPARC give rise to severe bone fragility in humans. SPARC negatively regulates glucose metabolism in hepatocellular carcinoma (HCC). Overexpression of SPARC inhibited glucose uptake and lactate product through downregulation of key enzymes of glucose metabolism.
Western blot analysis: 2-4 µg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Secreted |
| BioGrid: | 112560. 11 interactions. |
|
There are currently no product reviews
|
.png "ACE2/HEK293 Stable Cell Line")
