Polyclonal Antibody to Smad1 (Ab-206)
Figure 1: Western blot analysis of extracts from Hela and 3T3 cells using Smad1 (Ab-206) Antibody 35-1764 .
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Shipping Info:
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| Format : | Purified |
| Amount : | 100 µl |
| Isotype : | Rabbit IgG |
| Content : | 1.0 mg/ml,100 µl |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
Predicted MW: 60kd, Western blotting: 1: 500~1: 1000
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cytoplasm, Nucleus |
| Post transnational modification: | Ubiquitinated by SMAD-specific E3 ubiquitin ligase SMURF1, leading to its degradation. Monoubiquitinated, leading to prevent DNA-binding. Deubiquitination by USP15 alleviates inhibition and promotes activation of TGF-beta target genes. Dephosphorylation, probably by PPM1A, induces its export from the nucleus to the cytoplasm (By similarity). |
| Tissue Specificity: | Ubiquitous. Highest expression seen in the heart and skeletal muscle. |
| BioGrid: | 110261. 125 interactions. |
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