Polyclonal Antibody to SHP-1 (Phospho-Tyr536)

Figure 1: Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using SHP-1(Phospho-Tyr536) Antibody 35-1286 (left) or the same antibody preincubated with blocking peptide(right).

Polyclonal Antibody to SHP-1 (Phospho-Tyr536)

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Figure 1: Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using SHP-1(Phospho-Tyr536) Antibody 35-1286 (left) or the same antibody preincubated with blocking peptide(right).

Figure 2: Immunofluorescence staining of methanol-fixed Hela cells using SHP-1(Phospho-Tyr536) Antibody 35-1286 .

Product code: 35-1286

Clonality :	Polyclonal
Application :	IHC, IF
Reactivity :	Rat, Mouse, Human

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For estimated delivery dates, please contact us at [email protected]

Download TDS MSDS

Format :	Purified
Amount :	100 µl
Isotype :	Rabbit IgG
Content :	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage condition :	Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.


Gene :	PTPN6
Gene ID :	5777
Uniprot ID :	P29350
Alternative Name :	70Z-SHP, HCP, HCPH, Hematopoietic cell protein-tyrosine phosphatase, PTN6
Immunogen Information :	Peptide sequence around phosphorylation site of tyrosine 536 (S-E-Y(p)-G-N) derived from Human SHP-1.

Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus.

Predicted MW: 68kd, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location:	Cytoplasm, Nucleus
Post transnational modification:	Phosphorylated on tyrosine residues. Binding of KITLG/SCF to KIT increases tyrosine phosphorylation (By similarity). Phosphorylation at Tyr-564 enhances phosphatase activity.
Tissue Specificity:	Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells.
BioGrid:	111742. 127 interactions.