Polyclonal Antibody to S1PR1
Figure-1: Western blot analysis of S1PR1. Anti-S1PR1 antibody (11-8082) was used at 4 µg/ml on Liver lysate.
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Shipping Info:
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| Format : | Purified |
| Amount : | 100 µg |
| Isotype : | Rabbit IgG |
| Purification : | Protein A Chromatography |
| Content : | 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
Sphingosine-1-phosphate receptor 1 (S1P receptor 1 or S1P1), also known as endothelial differentiation gene 1 (EDG1) is a protein that in humans is encoded by the S1PR1 gene. S1PR1 plays an important role in cell migration reorganizing the actin cytoskeleton and by the formation of lamellipodia in response to the activity of sphingosine kinase SPHK1. Diseases associated with S1PR1 include follicular thyroid carcinoma and multiple sclerosis. It is mainly expressed on endothelial cells, vascular smooth muscle cells (low), fibroblasts, melanocytes and cells of epithelioid origin.
Western blot analysis: 2-4 µg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cell membrane, Endosome, Membrane raft |
| Post transnational modification: | S1P-induced endothelial cell migration requires the PKB/AKT1-mediated phosphorylation of the third intracellular loop at the Thr-236 residue. |
| Tissue Specificity: | Endothelial cells, and to a lesser extent, in vascular smooth muscle cells, fibroblasts, melanocytes, and cells of epithelioid origin. |
| BioGrid: | 108225. 30 interactions. |
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