Polyclonal Antibody to PKR (Phospho-Thr451)

Product code: 35-1264

Clonality : Polyclonal
Application : IHC
Reactivity : Human

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  •   50 µl

  •  100 µl

  • $374.00 

  • $437.00 

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Format : Purified
Amount : 100 µl
Isotype : Rabbit IgG
Content : Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : EIF2AK2
Gene ID : 5610
Uniprot ID : P19525
Alternative Name : ADRB2, E2AK2, EIF2AK2, EIF2aK, PRKR
Immunogen Information : Peptide sequence around phosphorylation site of threonine 451 (K-G-T(p)-L-R) derived from Human PKR.

Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection. Ingrid K. Ruf, et,al. (2005) J. Virol ; 79: 14562 - 14569. Christy M. Hebner,et,al. (2006) J. Gen. Virol ; 87: 3183 - 3193. Rika van Huizen, et,al. (2003) J. Biol. Chem ; 278: 15558 - 15564.

Predicted MW: 68kd, Immunohistochemistry: 1:50~1:100

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cytoplasm, Nucleus, Cytoplasm
Post transnational modification: Autophosphorylated on several Ser, Thr and Tyr residues. Autophosphorylation of Thr-451 is dependent on Thr-446 and is stimulated by dsRNA binding and dimerization. Autophosphorylation apparently leads to the activation of the kinase. Tyrosine autophosphorylation is essential for efficient dsRNA-binding, dimerization, and kinase activation.
Tissue Specificity: Highly expressed in thymus, spleen and bone marrow compared to non-hematopoietic tissues such as small intestine, liver, or kidney tissues. Colocalizes with GSK3B and TAU in the Alzheimer disease (AD) brain. Elevated levels seen in breast and colon carcinomas,and which correlates with tumor progression and invasiveness or risk of progression.
BioGrid: 111596. 101 interactions.
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