Polyclonal Antibody to PKM2

Product code: 35-1763

Clonality : Polyclonal
Application : WB, IF
Reactivity : Human

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Available Pack Size(s)

  •   50 µl

  •  100 µl

  • $374.00 

  • $437.00 

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Format : Purified
Amount : 100 µl
Isotype : Rabbit IgG
Content : Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : PKM
Gene ID : 5315
Uniprot ID : P14618
Alternative Name : PKM, PK3, OIP3, PK2
Immunogen Information : Peptide sequence around aa.405~409(T-S-D-P-T) derived from Human PKM2.
Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival. Christofk, H.R. et al. (2008) Nature 452, 230-3. Mazurek, S. et al. (2005) Semin Cancer Biol 15, 300-8. Dombrauckas, J.D. et al. (2005) Biochemistry 44, 9417-29. Hitosugi, T. et al. (2009) Sci Signal 2, ra73.

Predicted MW: 60kd, Western blotting: 1:500~1:1000

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cytoplasm, Nucleus
Post transnational modification: FGFR1-dependent tyrosine phosphorylation is reduced by interaction with TRIM35.
Tissue Specificity: Specifically expressed in proliferating cells, such as embryonic stem cells, embryonic carcinoma cells, as well as cancer cells.
BioGrid: 111332. 217 interactions.
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