Polyclonal Antibody to PER1

Fig-1: Western blot analysis of PER1. Anti- PER1 antibody (11-10027) was used at 4 µg/ml on Hela lysate.

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Product code: 11-10027

Clonality :	Polyclonal
Application :	WB
Reactivity :	Human

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Format :	Purified
Amount :	100 µg
Isotype :	Rabbit IgG
Purification :	Protein A Chromatography
Content :	25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition :	Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.


Gene :	PER1
Gene ID :	5187
Uniprot ID :	O15534
Alternative Name :	Circadian clock protein PERIOD 1, Circadian pacemaker protein Rigui, KIAA0482, PER, RIGUI
Immunogen Information :	A partial length recombinant PER1 protein (amino acids 1000-1200) was used as the immunogen for this antibody.

PER1 (period circadian clock 1) is an important core clock protein and members of the circadian family of proteins, involved in the regulation of normal cell proliferations and physiological rhythms of human beings. It is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain and its function is to regulate physiological rhythms, cell cycle and DNA damage response of normal living subjects. Aberrant expressions and altered rhythms of PER1 are highly linked to the carcinogenesis and development of malignant tumors, such as prostate cancer, colon cancer, leukocythemia and breast cancer.

Western blot analysis: 2-4 µg/ml

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location:	Nucleus, Cytoplasm
Post transnational modification:	Ubiquitinated; requires phosphorylation by CSNK1E and interaction with BTRC and FBXW11. Deubiquitinated by USP2 (By similarity).
Tissue Specificity:	Widely expressed. Expressed in hair follicles (at protein level).Found in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, kidney, spleen, thymus, prostate, testis, ovary and small intestine. Highest level in skeletal muscle.
BioGrid:	111210. 45 interactions.