Polyclonal Antibody to PAK1/PAK2/PAK3 (Ab-423/402/421)
Figure 1: Western blot analysis of extracts from MCF-7 and Hela cells using PAK1/PAK2/PAK3(Ab-423/402/421) Antibody 35-1511 .
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| Format : | Purified |
| Amount : | 100 µl |
| Isotype : | Rabbit IgG |
| Content : | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
| Gene : | PAK1 |
| Gene ID : | 5058 |
| Uniprot ID : | Q13153/Q13177 |
| Alternative Name : | p21-activated kinase 1, PAK-1, p65-PAK, Alpha-PAK |
| Immunogen Information : | Peptide sequence around aa.421~425/400~404/419~423 (R-S-T-M-V) derived from Human PAK1/PAK2/PAK3. |
The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2.
Predicted MW: 61-67 (PAK2) 68-74 (PAK1/3)kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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