Polyclonal Antibody to p21Cip1 (Phospho-Thr145)
Figure 1: Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using p21Cip1(Phospho-Thr145) Antibody 35-1193 (left) or the same antibody preincubated with blocking peptide(right).
Roll over image to zoom in
Shipping Info:
For estimated delivery dates, please contact us at [email protected]
Format : | Purified |
Amount : | 100 µl |
Isotype : | Rabbit IgG |
Content : | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression.
Predicted MW: 21kd, Immunohistochemistry: 1:50~1:100
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
Subcellular location: | Cytoplasm, Nucleus |
Post transnational modification: | Acetylation leads to protein stability. Acetylated in vitro on Lys-141, Lys-154, Lys-161 and Lys-163. Deacetylation by HDAC1 is prevented by competitive binding of C10orf90/FATS to HDAC1 (By similarity). |
Tissue Specificity: | Expressed in all adult tissues, with 5-fold lower levels observed in the brain. |
BioGrid: | 107460. 284 interactions. |
There are currently no product reviews
|