Polyclonal Antibody to p21Cip1 (Ab-145)

Product code: 35-1495

Clonality : Polyclonal
Application : WB
Reactivity : Human

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Available Pack Size(s)

  •   50 µl

  •  100 µl

  • $374.00 

  • $437.00 

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Format : Purified
Amount : 100 µl
Isotype : Rabbit IgG
Content : Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : CDKN1A
Gene ID : 1026
Uniprot ID : P38936
Alternative Name : CAP20, CDK-interacting protein 1, CDKN1, CDKN1A, CDN1A
Immunogen Information : Peptide sequence around aa.143~147 (R-Q-T-S-M) derived from Human p21Cip1.
May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression.

Predicted MW: 21kd, Western blotting: 1:500~1:1000

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cytoplasm, Nucleus
Post transnational modification: Acetylation leads to protein stability. Acetylated in vitro on Lys-141, Lys-154, Lys-161 and Lys-163. Deacetylation by HDAC1 is prevented by competitive binding of C10orf90/FATS to HDAC1 (By similarity).
Tissue Specificity: Expressed in all adult tissues, with 5-fold lower levels observed in the brain.
BioGrid: 107460. 284 interactions.
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