Polyclonal Antibody to NMDAR2B (phospho-Tyr1474)

Product code: 35-1161

Clonality : Polyclonal
Application : WB, IF
Reactivity : Rat, Mouse, Human

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  •   50 µl

  •  100 µl

  • $374.00 

  • $437.00 

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Format : Purified
Amount : 100 µl
Isotype : Rabbit IgG
Content : Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : GRIN2B
Gene ID : 2904
Uniprot ID : Q13224
Alternative Name : GRIN2B, NMDE2, NME2, NR2B, NR3
Immunogen Information : Peptide sequence around phosphorylation site of Tyr1474 (H-V-Y(p)-E-K) derived from Human NMDAR2B.

NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Babb TL et al.Epilepsy Res. 2005 Mar-Apr;64(1-2):23-30 Chazot PL. Curr Med Chem. 2004 Feb;11(3):389-96 Kakegawa W, et al.Eur J Neurosci. 2003 Feb;17(4):887-91

Predicted MW: 190kd, Western blotting: 1:500~1:1000, Immunofluorescence: 1:100~1:200

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cell membrane, Cell junction
Post transnational modification: Phosphorylated on tyrosine residues (By similarity). Phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity (By similarity).
Tissue Specificity: Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia.
BioGrid: 109161. 26 interactions.
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