Polyclonal Antibody to NMDAR2B (phospho-Tyr1474)
Figure 1: Immunofluorescence staining of methanol-fixed Hela cells using NMDAR2B(phospho-Tyr1474) Antibody 35-1161 .
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Shipping Info:
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| Format : | Purified |
| Amount : | 100 µl |
| Isotype : | Rabbit IgG |
| Content : | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Babb TL et al.Epilepsy Res. 2005 Mar-Apr;64(1-2):23-30 Chazot PL. Curr Med Chem. 2004 Feb;11(3):389-96 Kakegawa W, et al.Eur J Neurosci. 2003 Feb;17(4):887-91
Predicted MW: 190kd, Western blotting: 1:500~1:1000, Immunofluorescence: 1:100~1:200
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cell membrane, Cell junction |
| Post transnational modification: | Phosphorylated on tyrosine residues (By similarity). Phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity (By similarity). |
| Tissue Specificity: | Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia. |
| BioGrid: | 109161. 26 interactions. |
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