Polyclonal antibody to NLRP1/NALP1 (NAC-delta)

Product code: 20-1072

Clonality : Polyclonal
Application : IP, IHC, WB
Reactivity : Human

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50 µl
$260.00 

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Shipping Info:

Order now and get it on Wednesday November 06, 2024

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Format : Sera
Amount : 50 µl
Isotype : Rabbit IgG
Content : 50 µl sera
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : NLRP1
Gene ID : 22861
Uniprot ID : Q9C000
Alternative Name : NLRP1, CARD7, DEFCAP, KIAA0926, NAC, NALP1
Immunogen Information : A synthetic peptide of human NLRP1/NALP1/NAC/CARD7 (amino acids 161-180 PSSPDHESPSQESPNAPTST) was used as immunogen for this antibody

This antibody detects NLRP1; human NLRP1 is a 1473 amino acid protein. NLRP1, a member of NALP CLR subfamily, has an N-terminal pyrin domain (PYD), followed by an NBD, LRR, and a C-terminal CARD domain. NLRP1 is a component of both the inflammasome and apoptosome, suggesting that NLRP1 has important roles in both inflammation and apoptosis. The N-terminal domain consists of transactivation, CARD, Pyrin or BIR domains, or in some cases is undefined. The CLR  family, also known as the NOD family, has its ancient roots in the plant kingdom and is related to the disease resistance (R) gene family that mediates plant immune responses.However, multiple splice variants encoding distinct NLRP1 isoforms with varying amino acid lengths have been described and thus the molecular weight detected may vary depending on the isoform(s) expressed. 

WB: 1:1000-1:2000, IHC (paraffin): 1:1000-1:5000, IHC (frozen): Users should optimize, IP: 1:50-1:200

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cytoplasm, Cytoplasm, Inflammasome, Nucleus
Tissue Specificity: Widely expressed (PubMed:11113115, PubMed:17164409). Abundantly expressed in primary immune cells (isoform 1 and isoform 2), including in neutrophils, monocytes/macrophages, dendritic cells (mostly Langerhans cells), and B- and T-lymphocytes (at protein level) (PubMed:15285719, PubMed:17164409). Strongly expressed in epithelial cells lining the glandular epithelium, such as that of the gastrointestinal tract (stomach, small intestine, colon), the respiratory tract (trachea and bronchi), and the endometrial and endocervical glands, gallbladder, prostate, and breast (at protein level). In testis, expressed in spermatogonia and primary spermatocytes, but not in Sertoli cells (at protein level). In the brain, expressed in neurons, in particular in pyramidal ones and in oligodendrocytes, but not detected in microglia (at protein level) (PubMed:17164409). Expressed in adult and fetal ocular tissues, including in adult and 24-week old fetal choroid, sclera, cornea, and optic nerve, as well as in adult retina and fetal retina/retinal pigment epithelium (PubMed:23349227). Highly expressed in the skin throughout the epidermis and in dermal fibroblasts, in both glabrous skin and plantar skin. It is detected in keratinocytes, but not in melanocytes. Expressed in epidermal appendages such as hair follicles (PubMed:27662089).
BioGrid: 116529. 12 interactions.
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