Polyclonal Antibody to mPKR
Figure-1: Western blot analysis of mPKR. Anti-mPKR antibody (11-8119) was used at 1 µg/ml on m Heart lysate.
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| Format : | Purified |
| Amount : | 100 µg |
| Isotype : | Rabbit IgG |
| Purification : | Protein A Chromatography |
| Content : | 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
| Gene : | Eif2ak2 |
| Gene ID : | 19106 |
| Uniprot ID : | Q03963 |
| Alternative Name : | Eukaryotic translation initiation factor 2-alpha kinase 2, Interferon-inducible RNA-dependent protein kinase, P1/eIF-2A protein kinase, Protein kinase RNA-activated, Serine/threonine-protein kinase TIK, Tyrosine-protein kinase EIF2AK2, p68 kinase, Prkr, Tik |
| Immunogen Information : | A partial length recombinant mPKR protein (amino acids 295-515) was used as the immunogen for this antibody. |
Recommended dilutions: WB: 1-2 µg/ml. However, this need to be optimized based on the research applications.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cytoplasm, Nucleus, Cytoplasm |
| Post transnational modification: | Autophosphorylated on several Ser, Thr and Tyr residues. Autophosphorylation of Thr-414 is dependent on Thr-409 and is stimulated by dsRNA binding and dimerization. Autophosphorylation apparently leads to the activation of the kinase. Tyrosine autophosphorylation is essential for efficient dsRNA-binding, dimerization, and kinase activation (By similarity). |
| Tissue Specificity: | Expressed in heart, lung, brain, kidney, testes, thymus and bone marrow. |
| BioGrid: | 202376. 2 interactions. |
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