Polyclonal Antibody to Microtubule Associated Protein 2, MAP2A/B

Name: Polyclonal Antibody to Microtubule Associated Protein 2, MAP2A/B
Brand: Abeomics
SKU: 34-1064
Price: 500.0000 USD
Availability: InStock
Rating: 4.9 (10 reviews)

Figure-1: Immunofluorescent analysis of cortical neuron-glial cell culture from E20 rat stained with chicken pAb to microtubule associated protein 2 (MAP2),(34-1064), dilution 1:10,000 in red, and mouse mAb to MAP-tau,(34-1068), dilution 1:2,000, in green. The blue is DAPI staining of nuclear DNA. (34-1064) antibody stains dendrites and perikarya of neurons, while(34-1068) antibody labels neuronal perikarya, dendrites and also axonal process. As a result perikarya and dendrites appears orange-yellow, since they contain both MAP2 and tau, while axons are green.

Polyclonal Antibody to Microtubule Associated Protein 2, MAP2A/B

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Figure-1: Immunofluorescent analysis of cortical neuron-glial cell culture from E20 rat stained with chicken pAb to microtubule associated protein 2 (MAP2),(34-1064), dilution 1:10,000 in red, and mouse mAb to MAP-tau,(34-1068), dilution 1:2,000, in green. The blue is DAPI staining of nuclear DNA. (34-1064) antibody stains dendrites and perikarya of neurons, while(34-1068) antibody labels neuronal perikarya, dendrites and also axonal process. As a result perikarya and dendrites appears orange-yellow, since they contain both MAP2 and tau, while axons are green.

Figure-2: Western blot analysis of whole brain tissue lysates using chicken pAb to microtubule associated protein 2 (MAP2),(34-1064), dilution 1:50,000 in green: [1] protein standard (red), [2] adult rat brain, [3] embryonic E20 rat brain, [4] adult mouse brain. Strong band at ~280kDa mark corresponds to two major isoforms of MAP2 protein referred to as MAP2A and MAP2B. Smaller fragments of these isoforms are also detected if the antibody is used at higher concentrations.

Product code: 34-1064

Clonality :	Polyclonal
Application :	WB
Reactivity :	Human

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Shipping Info:

For estimated delivery dates, please contact us at [email protected]

Download TDS MSDS

Format :	Conc. IgY prep.
Amount :	50 µl
Isotype :	Chicken, IgY
Content :	Antibody is supplied as an aliquot of IgY preparation.
Storage condition :	Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.


Gene :	MAP2
Gene ID :	4133
Uniprot ID :	P11137
Immunogen Information :	Recombinant human projection domain sequence, amino acids 377-1505, our products Prot-r-MAP2-P1, Prot-r-MAP2-P2 and Prot-r-MAP2-P3.

WB: 1:20,000-50,000. IF/ICC and IHC: 1:5,000-1:10,000.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location:	Cytoplasm, Cell projection
Post transnational modification:	Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity). Isoform 2 is probably phosphorylated by PKA at Ser-323, Ser-354 and Ser-386 and by FYN at Tyr-67. The interaction with KNDC1 enhances MAP2 threonine phosphorylation (By similarity).
BioGrid:	110305. 48 interactions.