Polyclonal Antibody to MELK
Figure 1: Western blot analysis of extract from Rat brain tissue using MELK Antibody 35-1794
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| Format : | Purified |
| Amount : | 100 µl |
| Isotype : | Rabbit IgG |
| Content : | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
Phosphorylates ZNF622 and may contribute to its redirection to the nucleus. May be involved in the inhibition of spliceosome assembly during mitosis.
Seong H.-A., Gil M., Kim K.-T., Kim S.-J., Ha H. Biochem. J. 361:597-604(2002)
Vulsteke V., Beullens M., Boudrez A., Keppens S. Biol. Chem. 279:8642-8647(2004)
Predicted MW: 74kd, Western blotting: 1:500
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cell membrane |
| Post transnational modification: | Autophosphorylated: autophosphorylation of the T-loop at Thr-167 and Ser-171 is required for activation. Thr-478 phosphorylation during mitosis promotes interaction with PPP1R8 (Probable). |
| Tissue Specificity: | Expressed in placenta, kidney, thymus, testis, ovary and intestine. |
| BioGrid: | 115171. 59 interactions. |
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