Polyclonal Antibody to MEK1 (Phospho-Thr291)
Figure 1: Western blot analysis of extracts from HepG2 cells untreated or treated with PMA using MEK1(Phospho-Thr291) Antibody 35-1268 .
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| Format : | Purified |
| Amount : | 100 µl |
| Isotype : | Rabbit IgG |
| Content : | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates ERK1 and ERK2 MAP kinases.
Predicted MW: 45kd, Western blotting: 1:500~1:1000
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cytoplasm, Cytoplasm, Cytoplasm, Nucleus, Membrane |
| Post transnational modification: | Acetylation by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway. |
| Tissue Specificity: | Widely expressed, with extremely low levels in brain. |
| BioGrid: | 111590. 121 interactions. |
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