Polyclonal Antibody to MEK1 (Phospho-Ser221)

Product code: 35-1154

Clonality : Polyclonal
Application : WB, IHC, IF
Reactivity : Human, Mouse, Rat

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Available Pack Size(s)

  •   50 µl

  •  100 µl

  • $374.00 

  • $437.00 

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For estimated delivery dates, please contact us at [email protected]


Format : Purified
Amount : 100 µl
Isotype : Rabbit IgG
Content : Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : MAP2K1
Gene ID : 5604
Uniprot ID : Q02750
Alternative Name : ERK activator kinase 1, MAP kinase kinase 1, MAP2K1, MAPK/ERK kinase 1, MAPKK 1
Immunogen Information : Peptide sequence around phosphorylation site of serine 221 (A-N-S(p)-F-V) derived from Human MEK1.
Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates ERK1 and ERK2 MAP kinases. Zebisch A, et al. (2006) Cancer Res; 66(7): 3401-8. Luciano BS, et al. (2006)J Biol Chem; 279(50): 52117-23. Wang X, et al. (2003) Oncogene; 22(1): 109-16. Gopalbhai K, et al. (2003) J Biol Chem; 278(10): 8118-25. Ling MT, et al. (2002)Oncogene; 21(55): 8498-505.

Predicted MW: 45kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cytoplasm, Cytoplasm, Cytoplasm, Nucleus, Membrane
Post transnational modification: Acetylation by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway.
Tissue Specificity: Widely expressed, with extremely low levels in brain.
BioGrid: 111590. 121 interactions.
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