Polyclonal antibody to Mouse TRAF-5

Fig:1 Western blot analysis of m TRAF5 in normal human tissues using 20-1101 at 1:2000. TRAF5 is observed at ~64 kDa. Additional bands of lower molecular weight were seen in some cases, and may represent TRAF5 degradation fragments.

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Fig:1 Western blot analysis of m TRAF5 in normal human tissues using 20-1101 at 1:2000. TRAF5 is observed at ~64 kDa. Additional bands of lower molecular weight were seen in some cases, and may represent TRAF5 degradation fragments.

Fig:2 Formalin-fixed, paraffin-embedded mouse spleen stained for m TRAF5 expression using 20-1101 at 1:2000. Hematoxylin-eosin counterstain. A1 is a higher magnification of A.

Fig:3 Formalin-fixed, paraffin-embedded mouse tissue stained for m TRAF5 expression using 20-1101 at 1:2000. Hematoxylin-eosin counterstain. A, thymus. B, bone marrow.

Product code: 20-1101

Clonality :	Polyclonal
Application :	IP, IHC, WB
Reactivity :	Rat, Mouse, Human

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Download TDS MSDS

Format :	Sera
Amount :	50 µl
Isotype :	Rabbit IgG
Content :	50 µl sera
Storage condition :	Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.


Gene :	Traf5
Gene ID :	22033
Uniprot ID :	P70191
Alternative Name :	TNF receptor-associated factor 5
Immunogen Information :	A synthetic peptide of mouse TRAF-5 (amino acids 1-20 MAHSEEQAAVPCAFIRQNSG) was used as immunogen for this antibody

This antibody recognizes Mouse TRAF5 which is a 558 amino acid protein. The TRAF (TNF receptor-associated factor) family is a group of adapter proteins (TRAFs 1-6) that link a wide variety of cell surface receptors to diverse signaling cascades leading to the activation of NF-kB and mitogen-activated protein kinases. TRAFs are major signal transducers for both the TNF and IL- 1/TLR receptor superfamilies and collectively play important functions in both adaptive and innate immunity. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. TRAFs interact with a variety of proteins that regulate receptor-induced cell death or survival, and TRAF-mediated signaling can promote cell survival or interfere with death receptor-induced apoptosis. This antibody recognizes TRAF5. Mouse TRAF5 is a 558 amino acid protein.

WB: 1:1000-1:2000, IHC (paraffin): 1:1000-1:5000, IHC (frozen): Users should optimize, IP: 1:50-1:200

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location:	Cytoplasm, Cytoplasm
Tissue Specificity:	Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, and peripheral blood.
BioGrid:	204306. 4 interactions.