Polyclonal Antibody to Mouse TLR9

Figure-1: Western blot analysis of mTLR9. Anti- mTLR9 antibody (11-3036) was used at 2 µg/ml on (1) m Thymus, (2) m Spleen, (3) m Testis, (4) m Liver and (5) m Stomach lysates.

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Product code: 11-3036

Clonality :	Polyclonal
Application :	WB
Reactivity :	Mouse

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Format :	Purified
Amount :	100 µg
Isotype :	Rabbit IgG
Purification :	Protein A Chromatography
Content :	25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition :	Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.


Gene :	Tlr9
Gene ID :	81897
Uniprot ID :	Q9EQU3
Alternative Name :	Toll-like receptor 9, CD289
Immunogen Information :	Â Â A partial length recombinant m TLR9 protein (amino acids 200-450) was used as the immunogen for this antibody.

TLR9, a member of toll-like receptor family are central to the innate immunity by identifying pathogen associated molecular patterns (PAMPs). TLR9 identify unmethylated CpG dinucleotides present in bacterial DNA leading to NF-kB activation.

Western blot analysis: 1-2 µg/ml

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location:	Endoplasmic reticulum membrane, Endosome, Lysosome, Cytoplasmic vesicle
Post transnational modification:	Activated by proteolytic cleavage of the flexible loop between repeats LRR14 and LRR15 within the ectodomain (PubMed:18931679, PubMed:18820679). Cleavage requires UNC93B1 (PubMed:18820679). Proteolytically processed by first removing the majority of the ectodomain by either asparagine endopeptidase (AEP) or a cathepsin followed by a trimming event that is solely cathepsin mediated and required for optimal receptor signaling (PubMed:21402738).
Tissue Specificity:	Expressed in the basolateral region of gastric epithelial cells with high levels detected in antrum and body mucosa (at protein level). Detected in spleen and stomach at higher levels in C57BL/6 mice than BALB/C.
BioGrid:	219897. 1 interactions.