Polyclonal Antibody to LGR5(GPR49)
Figure 1: Western blot analysis of extracts from Hela, 3T3 and HepG2 cells using LGR5(GPR49) Antibody 35-1827 .
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| Format : | Purified |
| Amount : | 100 µl |
| Isotype : | Rabbit IgG |
| Content : | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
Orphan receptor. Stem cell marker of the intestinal epithelium and the hair follicule. Target gene of Wnt signaling. Yamamoto Y., Sakamoto M., Fujii G., Tsuiji H. Hepatology 37:528-533(2003) McClanahan T., Koseoglu S., Smith K. Cancer Biol. Ther. 5:419-426(2006) Becker L., Huang Q., Mashimo H.Scientific World Journal 8:1168-1176(2008)
Predicted MW: 95kd, Western blotting: 1:500~1:1000
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cell membrane, Golgi apparatus |
| Tissue Specificity: | Expressed in skeletal muscle, placenta, spinal cord, and various region of brain. Expressed at the base of crypts in colonic and small mucosa stem cells. In premalignant cancer expression is not restricted to the cript base. Overexpressed in cancers of the ovary, colon and liver. |
| BioGrid: | 114119. 7 interactions. |
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