Polyclonal Antibody to Lamin A/C
Figure-1: Immunofluorescent analysis of HeLa cells stained with chicken pAb to lamin A/C,(34-1057), dilution 1:2,000 in red, and costained with mouse mAb to actin,(34-1002), dilution 1:500, in green. The blue is Hoechst staining of nuclear DNA. The (34-1057) antibody specifically labels the nuclear lamina, while the actin antibody stains the submembranous actin-rich cytoskeleton, stress fibers and bundles of actin associated with cell adhesion sites.
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Shipping Info:
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| Format : | Conc. IgY prep. |
| Amount : | 100 µl |
| Isotype : | Chicken, IgY |
| Content : | Antibody is supplied as an aliquot of IgY preparation. |
| Storage condition : | Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles. |
WB: 1:2,000. IF/ICC 1:1,000
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Nucleus speckle |
| Post transnational modification: | Farnesylation of prelamin-A/C facilitates nuclear envelope targeting. |
| Tissue Specificity: | In the arteries, prelamin-A/C accumulation is not observed in young healthy vessels but is prevalent in medial vascular smooth muscle cells (VSMCs) from aged individuals and in atherosclerotic lesions, where it often colocalizes with senescent and degenerate VSMCs. Prelamin-A/C expression increases with age and disease. In normal aging, the accumulation of prelamin-A/C is caused in part by the down-regulation of ZMPSTE24/FACE1 in response to oxidative stress. |
| BioGrid: | 110186. 661 interactions. |
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