Polyclonal Antibody to JAK2 (Phospho-Tyr1007)

Product code: 35-1145

Clonality : Polyclonal
Application : IHC, WB
Reactivity : Rat, Mouse, Human

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Available Pack Size(s)

  •   50 µl

  •  100 µl

  • $374.00 

  • $437.00 

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Format : Purified
Amount : 100 µl
Isotype : Rabbit IgG
Content : Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : JAK2
Gene ID : 3717
Uniprot ID : O60674
Alternative Name : JAK-2, JAK2, Janus kinase 2, kinase Jak2
Immunogen Information : Peptide sequence around phosphorylation site of tyrosine 1007 (K-E-Y(p)-Y-K) derived from Human JAK2.

Plays a role in leptin signaling and control of body weight

Predicted MW: 125kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Endomembrane system, Cytoplasm, Nucleus
Post transnational modification: Autophosphorylated, leading to regulate its activity. Leptin promotes phosphorylation on tyrosine residues, including phosphorylation on Tyr-813 (By similarity). Autophosphorylation on Tyr-119 in response to EPO down-regulates its kinase activity (By similarity). Autophosphorylation on Tyr-868, Tyr-966 and Tyr-972 in response to growth hormone (GH) are required for maximal kinase activity (By similarity). Also phosphorylated by TEC (By similarity). Phosphorylated on tyrosine residues in response to interferon gamma signaling (PubMed:7615558, PubMed:7673114). Phosphorylated on tyrosine residues in response to a signaling cascade that is activated by increased cellular retinol (PubMed:21368206).
Tissue Specificity: Ubiquitously expressed throughout most tissues.
BioGrid: 109920. 109 interactions.
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