Polyclonal antibody to ITRAF
Fig:1 Immunohistochemical analysis of TANK/I-TRAF1 expression in formalin-fixed, paraffin-embedded normal human colon using 20-1068 at 1:2000. A-A3, low and high magnification images. Hematoxylin-eosin counterstain.
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| Format : | Sera |
| Amount : | 50 µl |
| Isotype : | Rabbit IgG |
| Content : | 50 µl sera |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
TANK/I-TRAF has also been shown to bind to other proteins in the NF-kB signaling pathway, including NEMO.This antibody recognizes TANK/I-TRAF, human TANK/I-TRAF is 425 amino acid protein.These families of proteins are associated with and transduce signals from members of the tumor necrosis factor receptor (TNFR) superfamily. TANK/I-TRAF (TRAF family member associated NF-kB activator/TRAF-interacting protein) that was first defined as a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction. The TANK/I-TRAF is thought to inhibit TRAF function by sequestering the TRAFs in the cytoplasm, thereby blocking their recruitment to the TNFR.
WB: 1:1000-1:2000, IHC (paraffin): 1:1000-1:5000, IHC (frozen): Users should optimize, IP: 1:50-1:200
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cytoplasm |
| Post transnational modification: | Phosphorylated by IKBKE. |
| Tissue Specificity: | Ubiquitous. |
| BioGrid: | 115328. 48 interactions. |
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