Polyclonal Antibody to Importin 7
Fig-1: Western blot analysis of Importin 7. Anti-Importin 7 antibody (11-8080) was used at 2 µg/ml on Hela lysate.
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| Format : | Purified |
| Amount : | 100 µg |
| Isotype : | Rabbit IgG |
| Purification : | Protein A Chromatography |
| Content : | 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
Importin 7 (IPO7) is a soluble nuclear transport factor that is required for efficient import. It mediates transport of hTERT into the nucleus. Efficient transport also requires the cytoplasmic nucleoporin Nup358, which was previously implicated in nuclear import of a subset of proteins. Importin 7 plays an important role in nuclear protein import either by acting as autonomous nuclear transport receptor, or as an adapter like protein in association with the importin-beta subunit KPNB1. It serves itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism.
Western blot analysis: 1-2 µg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cytoplasm, Nucleus |
| BioGrid: | 115782. 103 interactions. |
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