Polyclonal Antibody to HOIP/RNF31

Product code: 11-6006

Clonality : Polyclonal
Application : WB
Reactivity : Human

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Available Pack Size(s)

  •   25 µg

  •  100 µg

  • $100.00 

  • $270.00 

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Shipping Info:

Order now and get it on Friday November 22, 2024

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Format : Purified
Amount : 100 µg
Isotype : Rabbit IgG
Purification : Protein A Chromatography
Content : 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : RNF31
Gene ID : 55072
Uniprot ID : Q96EP0
Alternative Name : RNF31, ZIBRA
Immunogen Information : A partial length recombinant HOIP/RNF31 protein (amino acids 780-1020) was used as the immunogen for this antibody.
RNF31 (ring finger protein 31), also known as HOIP (HOIL-1-interacting protein) is an atypical E3 ubiquitin ligase that belongs to the RBR (RING-between-RING) family of E3 ligases and is the catalytic component of LUBAC (linear ubiquitin chain assembly complex), a multisubunit E3 ligase. Linear ubiquitin chains are assembled by the LUBAC (Linear Ubiquitin Chain Assembly Complex), which plays a critical role in the activation of the NF-kappaB pathway that is involved in various functions, including cell survival and inflammation. RNF31 is essential for the assembly and function of LUBAC and for various processes governing inflammation and immunity in both hematopoietic and nonhematopoietic cells.

Western blot analysis: 2-4 µg/ml

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cytoplasm
Tissue Specificity: Expressed in both normal and transformed breast epithelial cell lines.
BioGrid: 120389. 81 interactions.
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